All posts by Kim Smiley

Mechanical engineer, consultant and blogger for ThinkReliability, obsessive reader and big believer in lifelong learning
Root Cause

Common Birth Control Pills Have Increased Risk of Blood Clots

By Kim Smiley

Deaths of 24 Canadian women associated with the use of Yaz and Yasmin birth control pills have been making headlines in recent weeks.  South of the border in the US, more than $1 billion has already been paid out to settle thousands of lawsuits over alleged side effects.  Yaz and Yasmin are drospirenone-based birth control pills that are the most widely prescribed birth control pills worldwide so any concerns with the safety of the medication are alarming.

This issue can be analyzed by building a Cause Map, or visual root cause analysis.  A Cause Map lays out the many causes that contribute to an issue in an intuitive way that illustrates the cause-and-effect relationships.  The first step in the Cause Mapping process is to fill in an Outline with basic background information and to determine how the problem is affecting the overall goals of the organization.  In this example, side effects from the pills have been reported to have caused deaths and injuries.    Lawsuits associated with the side effects, specifically blood clots, have cost the drug manufacturer huge amounts of money as well as generated significant negative publicity, neither of which are outcomes a company is hoping for.

The complaints about severe and potentially deadly side effects have been focused on blood clots.  Blood clots are a known potential side effect of using any birth control pills.  It is believed that the estrogen used in birth control pills increases the clotting factors in blood making blood clots more likely.  The reason these specific pills are making headlines is that researchers have found that drospirenone-based birth control pills have a higher risk of blood clots than other birth control pills.  Researchers have estimated that the risk of blood cloths is 1.5 to 3 times higher with drospirenone-containing pills than with some other birth control pills.

For perspective, the FDA has stated that if 10,000 women who are not pregnant and do not use birth control pills are followed for one year, between 1 and 5 of these women will develop a blood clot and for women using birth control pills the range is 3 to 9.  But, and in my opinion this is a pretty big but, it’s worth knowing that the risk of blood clots during pregnancy is estimated to be 5 to 20 out of 10,000 and it’s even higher during first 12 weeks postpartum; estimated to be 40 to 65.

Please talk to your doctor if you have any concerns about blood clots or questions about whether a particular birth control pill is safe for you, especially if you think you may have other risk factors for blood clots.  If you’re curious about the symptoms of a blood clot or about other risk factors you can get more information here.

Please click on “Download PDF” above to see a high level Cause Map of this issue.

Root Cause

Promising New Cancer Drugs Use the Immune System

By Kim Smiley

A promising and potentially powerful new type of cancer treatment uses the immune system to fight tumors.   The drugs are still in early testing, but reports are that they shrunk tumors significantly in 15 to 50 percent of patients.  Patients with different types of cancer have also responded, which is an encouraging sign that the new treatment may have wide spread applications.

A Cause Map, or visual root cause analysis, can help illustrate how these new drugs work and explain why researchers and the companies developing them are so excited about them.  It may seem strange to use a root cause analysis technique on something positive, but it can be just as beneficial to understand why things are going well as it is investigate when problems crop up.  If you understand why a success occurred, the information may be used to reproduce it.   Building a “success” Cause Map is the same as any other Cause Map.  You start by identifying the impacted goals and then ask “why” questions.

In this example, the safety goal was impacted because the new type of cancer treatment shows promise, and the economic goal was impacted because the stock for the companies developing the new cancer drugs rose.   The new cancer treatment being developed shows promise because patients are responding to it and it is completely different from anything being used today.  The new immunotherapy treatments use the body’s own defenses, the immune system, to fight cancer.

You may wonder why drugs are needed at all if the immune system has the ability to fight cancer.  The answer lies in a  cancer tumor’s ability to hide from the T cells, the part of the immune system that detects bacteria and other “invaders”.  Tumors produce a protein on their surface that prevents T cells from detecting them so the immune system never even knows they are there.  A very simplified explanation is that the new drugs block the protein that hides tumors and allow T cells to detect them.   Once detected, the immune system will attack the cancer.

If immunotherapy is successfully developed, it would give doctors more options in treating cancer, especially those that don’t respond to the conventional treatments.  So far the side effects have also been minimal, far less than what is generally seen with chemotherapy and radiation treatments.

Much more research is needed before this type of drug is widely available, but the findings so far are positive enough to increase stock prices and excite experts in the field.   I have my fingers crossed that the end result is everything researchers are dreaming it will be.

Root Cause

Concern About a Resurgence of Black Lung Disease

By Kim Smiley 

Did you know that black lung disease has killed 70,000 coal miners since 1970?  Despite regulations designed to protect them, modern coal miners still face very real danger from coal dust.  Changes to the mining industry seem to be exacerbating this long standing issue.

Black lung disease, as coal workers’ pneumoconiosis is colloquially known, is caused by inhalation of coal dust, but there is more to the issue that needs to be understood.  The problem of miners suffering from black lung disease can be analyzed by building a Cause Map, a visual root cause analysis.  Cause Maps lay out the different causes that contribute to an issue visually to illustrate the cause-and-effect relationships.   (To view a high level Cause Map of this issue, click on “Download PDF” above.)

Coal dust is dangerous because it accumulates in the lungs and can cause long-term lung damage and breathing difficulties.  It is irreversible and there is no proven effective treatment.  Death can occur in severe cases.  The only option to fight this disease is prevention.

Black lung disease has a long history and concern about it first came to head in the 1960s.  A strike by 40,000 West Virginia coal miners pushed passage of the Federal Coal Mine Health and Safety Act of 1969.  This legislation limited coal dust exposure to 2 milligrams per cubic meter of air, which was significantly less than most miners were being exposed to at that time.  At first it seemed that the limits were effective in dramatically limiting black lung disease, but some are now worried about a resurgence of the disease.

Some speculate that changes in the mining industry are putting miners at greater risk for black lung disease.  The more dust that miners inhale, the greater the health risk and miners are both working longer hours and using equipment that potentially creates more dust.   The average workweek grew 11 hours since the 1970s which means miners are potentially exposed to dust for hundreds of more hours each year.  Technological advances have resulted in mining technology that is more powerful and can cut through coal faster, which can result in more dust.  The amount of coal produced per hour of work has nearly tripled since the 1970s.  These changes make it more challenging to prevent inhalation of dangerous levels of coal dust.  Increase in demand as well as the rising price of coal has driven these changes because it’s profitable to mine coal as quickly as possible.  Miners are also willing to work in the evolving conditions because mining provides a better living than other jobs available.

One of the most alarming pieces of evidence that cases of black lung may be increasing came from autopsies of the 29 miners killed in the blast at the Upper Big Branch mine in 2010.  The medical examiner was able to test tissue from 24 of the victims’ lungs and he found that 71% of those tested had black lung disease, a truly distressing percentage.  Some of the miners were relatively young and had a limited amount of time on the job.

There is no clear agreement on the best way to prevent black lung disease.  People are still trying to bound the problem and understand how significant the issue is.  But working to understand the problem is always the best first step to trying to solve it.

Root Cause

Health Risks to Young Athletes

By Kim Smiley

Deaths and serious injuries of young athletes make headlines every year.  So how do we ensure that participation in sports is as safe as possible?  The first step is to determine what is causing the deaths and understanding the factors involved.

The serious health risks to young athletes can be analyzed by building a Cause Map, an intuitive format for performing a root cause analysis.  A Cause Map visually lays out all the causes that contribute to an issue to show the cause-and-effect relationships to help illustrate the problem.  According to experts, some of the serious health threats to young athletes are sudden cardiac arrest, heat stroke and concussions.

The potential for concussions, especially in the more physical contact sports, has been getting a lot of attention in the media lately, but the most common cause of death of young athletes is sudden cardiac arrest.  Most cases of sudden cardiac arrest are caused by pre-existing heart conditions and the heart breaking part is that most of these are detectable and treatable.   Most of the heart conditions that cause sudden, unexpected death have few symptoms and can’t be found by a typical sports physical done in the US.  About two-thirds of the dangerous heart defects could be found by an electrocardiogram or EKG test, but these are not routinely done in the US.  The main factor preventing EKGs is the cost, which is not always covered by insurance.  Sudden cardiac arrest is also a risk that many people don’t know a lot about.

Concussions are also a risk for athletes of any age.  Concussions can have long term health consequences and occur when brain cells are damaged.  Concussions are mainly caused by impact to the head, but can also be caused by sudden jolts to the body that cause the brain to hit the inside of the skull.  Impacts during contact sports are a well-known cause of concussions, but typical sports activities like heading a soccer ball can also cause concussions.  Wearing the appropriate safety gear can help prevent concussions.  The rules of some sports also limit the more dangerous plays like helmet to helmet tackles in football.

Another significant risk to young athletes is heat stroke.  Heat stroke is usually preventable, but is still a significant risk and can cause death in extreme causes.  Heat stroke occurs when the internal temperature of the body rises above safe levels.  Young athletes are susceptible to heat stroke because many sports practice outside in hot weather. The typical modern, air conditioned life style increases the risk of heat stroke because athletes are generally less acclimated to the heat at the start of the season.  Athletes are most likely to suffer from heat stroke during the first few days of practice in hot temperatures. Gradually increasing workouts in warm temperatures to allow athletes to acclimate to the weather has been very effective at preventing heat stroke. For example, heat stroke rates dramatically decreased after the NCAA limited practice to three hours once a day for the first five days.

How quickly treatment is administered can also dramatically change the outcomes if an athlete is injured.  Quick action by trained personnel with the appropriate equipment can save lives.  According to a recent New Times Times article, only about 40 percent of high schools in the United States have a certified athletic trainer on staff and only about 70 percent have an automatic external defibrillator (AED).  AEDs are important because they can improve the chance for survival after sudden cardiac arrest by 60 percent or more.

So what is the best way to keep our young athletes safe?  This is a matter of lively debate.  Some people believe that the right answer is to require EKGs during pre-participation physicals, but the cost of performing EKGs on the 7.7 million high school athletes in the US is not trivial.  There is also the issue that EKGs, like most diagnostic tests, are not perfect and produce some false positives that would require more testing that raises costs.  Some believe the money could be better spent by hiring more trainers and buying more AEDs.  The answers aren’t simple, but the better we understand the problem the more informed the decisions will be.

Root Cause

Mom’s Saliva May Boost Infants’ Immune Systems

By Kim Smiley

A recent study found that “cleaning” a baby’s pacifier by sucking on it may actually have some lasting health benefits.  Researchers determined that babies given pacifiers exposed to their parents’ saliva developed fewer allergies.  It’s still not clear whether the benefits come from the actual oral cleaning of the pacifier or if this was just a marker of parents who had a more laid back approach to cleanliness, but scientists are finding increasing evidence that some exposure to more microbes early in life results in fewer allergies.

A Cause Map, a visual format for performing a root cause analysis, can be used to illustrate this issue.  A Cause Map intuitively shows the causes that contributed to an issue as well as the cause-and-effect relationships between them.  In this example, researchers found that infants whose parents cleaned their pacifiers by sucking on them, rather than by boiling or rinsing with tap water, had lower rates of eczema, fewer signs of asthma and smaller amounts of a type of white blood cell that rises in response to allergies.  The key seems to be that saliva contains traces of the parents’ gut microflora.  The infant’s immune system is stimulated by this exposure to their parents’ microflora and this seems to help prevent allergies, which are caused by the immune system responding to harmless inhaled or ingested proteins.  The study also found that children who are delivered vaginally develop fewer allergies than those who are born via cesarean, which limits exposure to bacteria during birth.

These findings are important because the percentage of the population in industrialized nations suffering from allergies has risen rapidly in the 20th century.  Currently, about a third of the children in affluent countries are affected by allergies.  Studies, such as this one, are being done to try and determine what is causing the increase in allergies but the causes are not definitively known yet.  Circumstantial evidence seems to point to lack of exposure to microbes in early childhood as a risk factor.  This study was relatively small and more research on a larger scale will need to be done, but it is beginning to seem that children who get a little dirty and put a few questionable things in their mouths actually benefit from the exposure.

So if you had a mom who cleaned stuff (and you…) with her spit, you have one more reason to thank her this Mother’s Day.  Or if you were that type of mom you have one less reason to feel guilty.

Check out our previous blog – Amish have few allergies

Root Cause

Study Finds that Fukushima Fallout is Affecting Babies in US

By Kim Smiley

A recent study found that babies born on the West Coast of the United States shortly after the Fukushima nuclear reactor meltdown have a higher rate of congenital hypothyroidism than those born a year earlier.  Thyroid issues have long been known to be associated with exposure to radiation and this finding feeds worries about the long term and long distance impact of the reactor disaster.

This issue can be analyzed by building a Cause Map, a visual root cause analysis, which intuitively lays out all the causes that contributed to an issue.  A Cause Map is built by asking “why” questions and adding the answers to the Cause Map to show the cause-and-effect relationships.

Why has the rate of congenital hypothyroidism increased?  This happened because the infants had radioactive iodine in their thyroids and radioactive iodine may affect the functioning of the thyroid if ingested.  If the thyroid doesn’t function properly, it can’t make the necessary hormones for healthy development and both growth and development can be stunted. The impacts of radioactive iodine are predominantly seen in the thyroid because ingested iodine concentrates in the thyroid where it is used to produce hormones.  The body can’t distinguish between stable and radioactive isotopes of iodine and it will store whatever iodine is available so ingested radioactive iodine can be kept within the body long enough to cause damage.

In the cases of fetuses, the mother passes iodine to her baby.  If pregnant woman ingests radioactive iodine, some of it will likely end up in the thyroid of her baby who needs the iodine to develop properly.  In this example, pregnant women on the West Coast were exposed to significantly higher than normal levels of iodione-131 following the Fukushima meltdown. Iodione-131 is a fission product that is created in a nuclear reactor when atoms are split.  When the reactor containment failed, radioactive isotopes of iodine were released into the environment along with other fission products.  Winds carried some of the radiation across the Pacific Ocean. Iodine-131 concentrations in precipitation in the United States were up to 211 times above normal in the days following the accident.  Some of this radioactive iodine found its way into the food supply and was ingested by people, some of them pregnant women causing the increase in cases of congenital hypothyroidism.

The good news is that congenital hypothyroidism with can be treated if found early.  The bad news is that there may be more health issues from the Fukushima meltdown in places outside of Japan discovered in the future.  The reality is that more than two years after the event we still don’t know what all the impacts of the radiation will be, both in Japan which has obviously suffered the most and in other countries.

 

 

Root Cause

FDA Inspections Find Issues at Compounding Pharmacies

By Kim Smiley

Unsafe practices at compounding pharmacies were found during recent Federal Drug Agency (FDA) inspections.  The FDA visited about 30 pharmacies in 18 different states, focusing on the production of sterile drugs which was determined to be the highest risk to patient safety.   The inspection findings include a number of potential contamination issues such as inadequate ventilation, unidentified particles in vials of supposedly sterile medications, cleanliness issues in clean rooms such as rust and mold, and insufficient microbiological testing. Interest in compounding pharmacies was increased after the fall 2012 outbreak of fungal meningitis that killed 50 and sickened hundreds was traced back to compounded injectable steroid medication that had been shipped across the country.

A root cause analysis of the issues at compounding pharmacies can be done by building a Cause Map.  A Cause Map visually lays out the different causes that contribute to an issue and is a way to intuitively illustrate the problem.  Compounding medications are an issue because they can pose both indirect and direct risks to patient safety and patients are using them.   The indirect risk is that patients may inadvertently use an ineffective medication.  Compounded medications are not regulated by the FDA and have not gone through a formal approval process that requires extensive testing.  Medications that are compounded can also be a direct risk to patient safety if they are contaminated or sub- or super-potent.  As the fatal fungal meningitis outbreak unfortunately demonstrated, contamination of supposedly sterile drugs can have deadly consequences. Compounded drugs are receiving more attention than traditionally manufactured drugs because some of the facilities may have less oversight and the recent investigations found more issues with the work processes at the compounding pharmacies than is typically discovered at drug manufacturing facilities.

Many are asking questions about how compounding pharmacies are regulated and overseen.  Compared to drug manufacturers, the FDA’s regulatory authority over compounding pharmacies is limited.  Compounding pharmacies are not generally even required to inform the FDA what drugs they are making or register with the FDA.  State boards of pharmacy regulate the compounding pharmacies and the FDA typically becomes involved only to do for-cause inspections upon receiving reports or complaints or when states have requested assistance.

It’s worth noting that compounding pharmacies do serve an important need.  Some individuals cannot be treated with standard manufactured medication.  An example of this is when somebody is allergic to an inactive ingredient, such as a dye, in an approved medication.  The real concern is that the creation and  use of compounded medications seems to be changing from its traditional function.  According to Ilisa Bernstein, acting director of Center for Drug Evaluation and Research’s Office of Compliance, “Some aspects of these firms’ operations appear more consistent with those of drug manufacturers than with those of traditional pharmacies. Some firms make large amounts of drugs that appear to be copies of FDA-approved, commercially available drugs when it does not appear that there is a medical need for an individual patient to receive a compounded version of the drug.”

There have been a number of voluntarily recalls as a result of the recent inspections.  The FDA and state regulatory boards are working together to address the issues that were uncovered.  Additionally, the FDA is pushing for new legislative authority over the highest-risk compounding pharmacies, but there isn’t agreement on whether changes are necessary and it’s not clear what the outcome will be.

For more information about compounded medications, please visit the FDA website.

Root Cause

Lead Poisoning Still An Issue for US Children

by Kim Smiley

Lead poisoning has once again hit the news with scary headlines such as “Blood Lead Levels High In 535,000 Kids In The USA” and “Despite Big Progress, Many Kids Have High Lead Levels in Blood“.   But what do these articles actually mean in context?  What does “many kids” refer to and how alarmed should we be?

A tool like a Cause Map, a visual method for performing a root cause analysis, can be useful to analyze issues like this one.   The first step in the Cause Mapping process is to define the problem and that alone can help clarify an issue.   Part of defining the problem is to determine which overall organizational goals are being impacted by the problem.   In this example, it becomes clear that there are really two different, but related goals that need to be considered.  The most basic goal is the safety goal.  The safety goal is being impacted because children are still being negatively impacted by exposure to lead in the United States, despite decades of work to dramatically reduce lead in the environment.  The second issue is that 2.6% of children in the US have blood lead levels (BLLs)  higher than the levels set by the Center for Disease and Control (CDC), an impact to the regulatory goal.

It’s clear why exposure to lead remains a concern. Ingestion of lead is dangerous, especially to small children. High levels of lead in the body can have severe and immediate consequences such as coma, convulsions and even death.  Lower levels of lead have been shown to cause lower IQs, behavior issues, hearing problems and a number of problems in organs in the body.  Problems with lead exposure are well known and the use of lead has been dramatically reduced.  Use of lead in household paints, one of the most common sources of ingested lead, was banned in 1978.  However, paint is still one of the primary sources of lead contamination because many children live in houses built before 1978.  Paint chips containing lead can still be an issue, especially if an older house has loose paint or is undergoing a renovation.  Use of lead in gasoline, a common source of soil contamination, was phased out by the end of the 1980s.

The second issue of concern is that 2.6% of children have blood lead levels above the limit set by the CDC.  What does this mean?  If this problem is hitting headlines, are things getting worse?  One important piece of data is that the CDC lowered the limit for young children in 2012 to 5 µg/dL from 10 µg/dL.  Why was the limit lowered?  The limit was lowered because no amount of lead has been determined to be safe for young children and less lead is always better.  The new limit of 5 µg/dL was based on lead levels in the 2.5% of children with the highest levels.  It was a way to target the children most at risk and it marked a shift towards a more prevention-based approach.

Is it okay that 2.6% of children still have blood lead levels above the target?  Of course not.  Is there still work to do in preventing lead exposure?  Many people believe there is.  But the alarming headlines may not tell the whole story.  Here are some other facts that help put the issue of lead exposure in historical context: an estimated 88% of children aged 1 to 5 had blood lead levels at or above 10 mcg/dL from 1976 to 1980; from 1991-1994 it was 4.4% , from 1999-2002 it was 1.6% and it dropped to 0.8% in 2007-2010.    Lead exposure is a still an issue, but it’s an issue that has been drastically improved.

To view a Cause Map of this issue, click on “Download PDF” above.  For more information, click here to visit the CDC’s information page about lead.

 

Root Cause

US Stockpiles Smallpox Medicine, Fear of Bioterrorism

By Kim Smiley

The last case of smallpox in the United States occurred in 1949, but the government recently made headlines for spending $463 million on enough medicine to treat two million people infected with the disease.  It is feared that the deadly and disfiguring disease could be used by bioterrorists and the government wanted to be prepared in the event of an attack.

The concern that smallpox could be used for bioterrorism can be analyzed by building a Cause Map, a visual root cause analysis.  The first step is to fill in an Outline with the background information for the problem and determine which goals are impacted.  In this example, the safety goal is impacted because there is a chance of many deaths if smallpox is released, the financial goal is impacted because hundreds of millions of dollars were spent on treatment for smallpox and the customer service goal is impacted because people are nervous about the potential for smallpox bioterrorism.  Once the impacts to the goals are determined, the Cause Map is built by asking “why” questions.

Why is there a potential for many deaths?  This is true because there is the potential that a smallpox outbreak could happen, many are unprotected against smallpox, and smallpox is a very deadly, highly contagious disease.  An outbreak could occur if bioterrorists released smallpox because the virus still exists in research labs in the US and Russia.  Advances in the genetic field have also opened the possibility that the smallpox virus could be  re-engineered and essentially created in a lab anywhere in the world.   Many people are unprotected against smallpox because the vaccination program ended in 1980 when it was eradicated.  People vaccinated prior to 1980 likely maintain some level of protection from smallpox, but the effectiveness of the vaccine degrades over time and they are no longer fully protected.  Smallpox is a very dangerous disease because it has fatality rate of about 30% and many survivors are left blind or disfigured.  It’s also very contagious and can be spread without direct contact because it can be transmitted via aerosolized droplets from saliva and other body fluids.

The financial goal is also worth considering.  Hundreds of millions of dollars have been spent to prepare for a potential smallpox attack.  The government has long stockpiled smallpox vaccines in the event they were needed, but the move to buy medicine to treat the disease is fairly recent and substantially more expensive than just buying vaccines.  This option has only recently been a possibility because there was no treatment for smallpox until now.  A private company developed antiviral medicine to treat smallpox in the hope that it would be profitable.

Developing solutions to problems that might occur is always tricky and likely to cause debate.  There are many reasons why a smallpox bioterrorism attack is frightening, but how much money should the US government spend to prepare for an attack?    How much preparation is enough?  There is no simple answer, but it’s important to understand these types of problems to the best of our ability to help make well thought out and reasonable decisions.

To view a high level Cause Map of this problem, click on “Download PDF” above.

 

 

 

Root Cause

Cases of Deadly ‘Superbugs’ on the Rise in US

By Kim Smiley

A new antibiotic resistant strain of bacteria is causing deaths and raising flags in US healthcare facilities. The bacteria is called Carbapenem-Resistant Enterobacteriaceae, often shortened to CRE, and is named for its ability to resist carbapenem antibiotics, the last resort treatment for antibiotic resistant bacteria. The fatality rate for those infected may be as high as 50 percent. In 2012, 4 percent of hospitals reported cases of CRE, up from about 1 percent a decade ago. The situation at long-term care hospitals is significantly worse, with 18 percent reporting cases last year.

The issue of CRE can be analyzed by building a Cause Map, a visual method for performing a root cause analysis. The first step is to create an Outline that documents all the background information for an issue. How the problem impacts the overall organization goals is also listed on the bottom of the Outline. In this example, the safety goal is obviously impacted since there have been patient deaths. After the Outline is completed, the second step is to build the Cause Map. The Cause Map is built by asking “why” questions to determine what causes contributed to the issue and then arranging the causes visually to show cause-and-effect relationships. Why have there been patient deaths?  This has occurred because they were infected with CRE and CRE infections are dangerous.

People are being exposed to CRE primarily in healthcare settings. CRE is being passed between patients within the same facility and between healthcare facilities as infected patients are transferred to different healthcare settings. Exposure is occurring between patients because infected patients may not be identified or adequately isolated. Many healthcare facilities do not have the capability to test for CRE and it’s also difficult to identify who should be tested since some patients who carry the bacteria are not symptomatic. CRE also tends to infect individuals who have other health issues and weakened immune systems. Treatment of the other issues may involve invasive medical devices, such as catheters, that can provide a pathway for infection into the body.

CRE infections are dangerous because they have a high rate of fatality, up to 50 percent according to the CDC, and they are difficult to treat. CRE are resistant to virtually all antibiotics. This strain of bacteria is also particularly worrying because they can transfer their resistance to other bacteria within their family, compounding the problem. Antibiotic resistant bacteria have developed over the years because of the wide use of antibiotics. Each time antibiotics are used, bacteria have a chance to evolve and they have over the years.

The final step in the Cause Mapping process is to find solutions that would reduce the risk of the problem in the future. In this example, there isn’t an easy solution. There are no promising new antibiotics in development at this time that would likely be able to treat CRE infections so the best hope is to prevent the bacteria from spreading. The CDC has recommended steps such as identifying and isolating infected patients.

This example also show important it is to track the effectiveness of solutions after they are implemented because there can be unintended consequences that show up later on. Antibiotics have saved thousands of lives, but they are becoming less effective as bacteria develop resistance to them. New solutions will be needed to prevent or fight these types of infections in the future. Cause Mapping is a useful tool to document evolving issues because they can easily be adjusted and added to as new information is available.

To view a high level Cause Map, click on “Download PDF” above.